Craniosacral therapy (CST), or cranial-sacral therapy, is a form of bodywork or alternative therapy focused primarily on the concept of "primary respiration" and regulating the flow of cerebrospinal fluid by using therapeutic touch to manipulate the synarthrodial joints of the cranium. To do this, a practitioner will apply light touches to a patient's skull, face, spine and pelvis Craniosacral therapy was developed by John Upledger, D.O. in the 1970s, and is loosely based on osteopathy in the cranial field (OCF), which was developed in the 1930s by William Garner Sutherland.

Practitioners of craniosacral therapy assert that there are small, rhythmic motions of the cranial bones attributed to cerebrospinal fluid pressure or arterial pressure. The premise of CST is that palpation of the cranium can be used to detect this rhythmic movement of the cranial bones and selective pressures may be used to manipulate the cranial bones to achieve a therapeutic result. However, the degree of mobility and compliance of the cranial bones is considered controversial and is a critically important concept in craniosacral therapy.

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